L’estratto di carciofo utile per abbassare l’iperglicemia

Phytother Res. 2013 Feb 25. doi: 10.1002/ptr.4950.

Metabolic Management in Overweight Subjects with Naive Impaired Fasting Glycaemia by Means of a Highly Standardized Extract From Cynara scolymus: A Double-blind,Placebo-controlled, Randomized Clinical Trial.

Rondanelli M, Opizzi A, Faliva M, Sala P, Perna S, Riva A, Morazzoni P,
Bombardelli E, Giacosa A.

University of Pavia, Health Sciences Department, Section of Human Nutrition,
Azienda di Servizi alla Persona, Via Emilia n.12, Pavia, Italy.

The aim of this study is to evaluate the efficacy of a dietary supplementation
with an extract from Cynara scolymus (Cs) on the glucose pattern in a group of
patients with naive impaired fasting glycaemia (IFG). A randomized, double-blind,
placebo-controlled trial has been performed in 55 overweight subjects with IFG
(fasting blood glucose [FBG]: 6.11 ± 0.56 mmol/l). These subjects were randomly
assigned to supplement their diet with either an extract from Cs (600 mg/d) (26
subjects) or placebo (29 matched subjects) for 8 weeks. The decrease of FBG was
the primary endpoint. The assessment of Homeostatic Metabolic Assessment (HOMA),
glycosylated haemoglobin, A1c-Derived Average Glucose (ADAG), lipidic pattern and
anthropometric parameters were the secondary endpoints. The within groups and
percent changes from baseline were analyzed by the signed rank test. The
comparison between groups was performed by Wilcoxon’s two sample test. The
supplemented group had significant decreases of: FBG (-9.6%), HOMA (-11.7%),
glycosylated haemoglobin (-2.3%), ADAG (-3.1%) and lipidic pattern. The placebo
group did not show any significant difference. Compared with the placebo, the
supplemented group showed a significant difference in FBG, HOMA and lipidic
pattern. These data demonstrate the efficacy of Cs extract on the reduction of
glycometabolic parameters in overweight subjects with IFG. (Questi dati dimostrano l’efficacia dell’estratto di Carciofo sulla riduzione dei parametri glicometabolici in soggetti obesi con iperglicemia a digiuno)

Copyright © 2013 John Wiley & Sons, Ltd.


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